|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Mannan-binding lectin (MBL) - associated serine protease 2 (MASP-2) co-activates the lectin pathway of complement in response to several viral infections.
|
27588826 |
2016 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Evaluation of TRY1 and TRY2 mRNA expression by multiplex RT-PCR in a series of 20 colon tumor tissues representative of the range of tumor progression showed that TRY2 mRNA was expressed much more commonly than TRY1 mRNA in normal mucosa (26% vs. 6%) as well as in primary tumor tissues (65% vs. 15%).
|
11391623 |
2001 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The effects of invasion were analyzed using trypsin-2 over-expressing human tongue squamous cell carcinoma cells (Try2-HSC-3) in vitro and in vivo.
|
22909050 |
2012 |
|
Tropical infectious disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we characterize the structural and proteolytic attributes of serine protease 2 (SmSP2) from Schistosoma mansoni, one of the major species responsible for the tropical infectious disease, schistosomiasis.
|
29677188 |
2018 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As anionic trypsinogen (PRSS2) G191R protects against chronic pancreatitis in Europeans, we investigated whether this variant protects from TCP in Indians.
|
19077465 |
2009 |
|
Tongue Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms.
|
22909050 |
2012 |
|
Synovitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue.
|
16192646 |
2005 |
|
Steatorrhea
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of mannose-binding lectin-associated serine protease-2 expression in esophageal squamous cell carcinoma.
|
16395704 |
2006 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas.
|
18062964 |
2008 |
|
Sporotrichosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mannose-Binding Lectin and Mannose-Binding Lectin-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis.
|
31549610 |
2019 |
|
Splanchnic vein thrombosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, immunohistochemical staining detected trypsin-2 in the fibroblast-like synovial lining and in stromal cells of human rheumatoid arthritis synovial membrane.
|
16192646 |
2005 |
|
Recurrent pancreatitis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Psychotic Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Analysis of Parkinson's disease cases alone indicated that serpin-A5 and serpin-A13, and trypsin-2 expression in midbrain and cerebral cortex was different in cases with a high incidence of L-DOPA-induced dyskinesia and psychosis compared to those with low levels of these treatment-induced side effects.
|
25982926 |
2015 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancer.
|
15651064 |
2005 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas.
|
18062964 |
2008 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults.
|
18582923 |
2008 |
|
Pleural effusion disorder
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Patent ductus arteriosus - persisting type
|
0.010 |
Biomarker
|
disease |
BEFREE |
Five decreased proteins (platelet factor 4, fibrinogen, von Willebrand factor, collagen, and mannose binding lectin-associated serine protease-2) and one increased protein (fibronectin) may increase the risk of patent ductus arteriosus.
|
30480800 |
2019 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Five decreased proteins (platelet factor 4, fibrinogen, von Willebrand factor, collagen, and mannose binding lectin-associated serine protease-2) and one increased protein (fibronectin) may increase the risk of patent ductus arteriosus.
|
30480800 |
2019 |
|
Parkinson Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study examined expression of PAR2 and endogenous proteinase activators (trypsin-2, mast cell tryptase) and proteinase inhibitors (serpin-A5, serpin-A13) in areas vulnerable and resistant to neurodegeneration in Parkinson's disease at different Braak α-synuclein stages of the disease in post-mortem brain.
|
25982926 |
2015 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.
|
15776435 |
2005 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.
|
15776435 |
2005 |
|
Pancreatitis, Chronic
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis.
|
18362849 |
2008 |